Table 2. Summary of Known and Suspected Health Effects of Diethylstilbestrol Exposure*
| Well-Established | Probable | Possible | Speculative† |
|---|---|---|---|
Cervicovaginal clear-cell adenocarcinoma (DES daughters) Vaginal epthelial changes (DES daughters) Reproductive-tract anomalies (DES daughters) Premature births (DES daughters) Breast cancer (DES mothers) |
Ectopic Pregnancies (DES daughters) Infertility (DES daughters) Reproductive-tract anomalies (DES sons) |
Cervical dysplasia carcinoma in situ (DES daughters) Autoimmune disorders (DES daughters) Infertility (DES sons) Testicular cancer (DES sons) |
Breast cancer (DES daughters) Psychosexual effect (daughters and sons) Prostatic hyperplasia, cancer (DES sons) Third generation effects (DES grandchildren |
|
* DES = diethylstilbestrol † Primarily based on animal models | |||