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Table 2. Summary of Known and Suspected Health Effects of Diethylstilbestrol Exposure*

Well-Established Probable Possible Speculative†

Cervicovaginal clear-cell adenocarcinoma (DES daughters)

Vaginal epthelial changes (DES daughters)

Reproductive-tract anomalies (DES daughters)

Premature births (DES daughters)

Breast cancer (DES mothers)

Ectopic Pregnancies (DES daughters)

Infertility (DES daughters)

Reproductive-tract anomalies (DES sons)

Cervical dysplasia carcinoma in situ (DES daughters)

Autoimmune disorders (DES daughters)

Infertility (DES sons)

Testicular cancer (DES sons)

Breast cancer (DES daughters)

Psychosexual effect (daughters and sons)

Prostatic hyperplasia, cancer (DES sons)

Third generation effects (DES grandchildren

* DES = diethylstilbestrol
† Primarily based on animal models

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